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Large, confluent proliferation centers (adverse) ( Blood 2016 127:2375).CD49d (> 30% positive in CLL cells) has been associated with progression ( Blood 2020 135:1244).CD38 (> 30% positive in CLL cells by flow cytometry) is adverse, ZAP70 expression (> 20%) is adverse.13q deletion is favorable, 11q deletion is unfavorable, trisomy 12 is associated with intermediate prognosis.Complex karyotype (10 - 15%, 3 or more unrelated abnormalities) is adverse ( Blood 2019 133:1205).TP53 mutation / 17p deletion is adverse, is associated with poor response to traditional chemotherapeutic regimens patients may respond to newer agents ( J Oncol Pract 2017 13:371).Beta-2 microglobulin: high levels associated with high tumor burden and adverse prognosis.Clinical stage (based on physical manifestations and blood parameters): Rai and Binet systems.Gradual accumulation of genetic alterations, however, no clear malignant transformation event recognizable.CLL-MUT (mutated): many mutations in the IGH gene (CLL-UM (unmutated): few mutations in the IGH gene (≥ 98% homology with germline sequence), associated with more proliferation, more aggressive disease course.2 types of CLL that do not show conversion during disease course:.30% of cases show stereotyped B cell receptors with identical or nearly identical structure ( Leukemia 2019 33:287).Some evidence indicating self stimulation by B cell receptors ( Cell Res 2013 23:182).Evidence for autoreactivity of B cell receptors (antigens recognized by studies are related to normal tissue maintenance, apoptosis, atherosclerosis, common infections, etc.) ( Front Oncol 2020 10:592205).B cell receptors show evidence of selection by antigens, B cell receptor signaling is crucial in survival of CLL cells ( Front Oncol 2020 10:592205).Clonal restriction of specific B cell populations with reduced competition of remaining B cell clones due to aging.In addition, please not that we accept Trainers only in NM/M.
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The following list outlines how many Porocredits we are offering for each English-language Pokemon single, but the best way to ensure you know how many Porocredits you’ll receive is to bring your cards into the shop for appraisal. One Porocredit is the same as one euro… but you can only use them to make more reindeer magic with us here at Poromagia. Sadly our puns don’t translate particularly well, you’ll just have to believe us when we tell you that Porocredits are our own bit of reindeer magic: a special in-store currency that you can use to pay for any product at the Poromagia brick-and-mortar shop in Pasila or here on our webshop. For the uninitiated, Poromagia means “reindeer magic” here in Finland, but here at Poromagia we like to bring everyone in on the fun.